The fusion of myoblasts into multinucleate syncytia plays a fundamental role in muscle
function, as it supports the formation of extended sarcomeric arrays, or myofibrils, within a …

Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …

Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to
the substratum but can also degrade components of the extracellular matrix. Accordingly …

Abstract The Wiskott–Aldrich syndrome protein (WASP) is an important regulator of the actin
cytoskeleton that is required for many haematopoietic and immune cell functions, including …

Osteoclasts are multinucleated cells that are responsible for resorption of bone, and
increased activity of these cells is associated with several common bone diseases, including …

Macrophages are terminally differentiated cells of the mononuclear phagocytic lineage and
develop under the stimulus of their primary growth and differentiation factor, CSF‐1 …

Cell–matrix adhesions are essential for cell migration, tissue organization and
differentiation, therefore playing central roles in embryonic development, remodeling and …

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local
architectures to sustain nearly all cellular activities in response to a myriad of stimuli …

N-WASP is a major cytoskeletal regulator that stimulates Arp2/3-mediated actin nucleation.
Here, we identify a nucleation-independent pathway by which N-WASP regulates the …

The Arp2/3 complex is a molecular machine that generates branched actin networks
responsible for membrane remodeling during cell migration, endocytosis, and other …