Tumor metastasis is a major contributor to the death of cancer patients. It is driven not only
by the intrinsic alterations in tumor cells, but also by the implicated cross-talk between …

Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within
tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

During tumor progression, circulating monocytes and macrophages are actively recruited
into tumors where they alter the tumor microenvironment to accelerate tumor progression …

The respective antitumoral and protumoral roles of M1 and M2 tumor-associated
macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer …

Cholesterol is a multifaceted metabolite that is known to modulate processes in cancer,
atherosclerosis, and autoimmunity. A common denominator between these diseases …

Macrophages represent a major cell type of innate immunity and have emerged as a critical
player and therapeutic target in many chronic inflammatory diseases. Hepatic macrophages …

The tumour microenvironment (TME) is composed of extracellular matrix and non-mutated
cells supporting tumour growth and development. Tumour-associated macrophages (TAMs) …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …