Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications
Alcohol dehydrogenases (ADHs) catalyze the reversible reduction of a carbonyl group to its
corresponding alcohol. ADHs are widely employed for organic synthesis due to their lack of …
corresponding alcohol. ADHs are widely employed for organic synthesis due to their lack of …
Biocatalytic asymmetric reduction of prochiral bulky-bulky ketones
Biocatalytic asymmetric reduction of prochiral bulky-bulky ketones is an attractive approach
to produce their corresponding valuable enantiopure alcohols. These ketones contain alkyl …
to produce their corresponding valuable enantiopure alcohols. These ketones contain alkyl …
Stereochemistry in asymmetric reduction of bulky–bulky ketones by alcohol dehydrogenases
Biocatalyzed asymmetric reduction of ketones is one of the most cost-effective and
environmentally friendly approaches for preparing chiral alcohols. However, few natural …
environmentally friendly approaches for preparing chiral alcohols. However, few natural …
Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
Biocatalytic production of both enantiomers of optically active alcohols with high
enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an …
enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an …
In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols
The direct and efficient conversion of alcohols into amines is a pivotal transformation in
chemistry. Here, we present an artificial, oxidation–reduction, biocatalytic network that …
chemistry. Here, we present an artificial, oxidation–reduction, biocatalytic network that …
Biocatalytic asymmetric synthesis of (R)‐1‐tetralol using Lactobacillus paracasei BD101
Asymmetric bioreduction of ketones is a fundamental process in the production of organic
molecules. Compounds containing tetralone rings are found in the structure of many …
molecules. Compounds containing tetralone rings are found in the structure of many …
Secondary Alcohol Dehydrogenases from Thermoanaerobacter pseudoethanolicus and Thermoanaerobacter brockii as Robust Catalysts
Alcohol dehydrogenases (ADHs) are an important type of enzyme that have significant
applications as biocatalysts. Secondary ADHs from Thermoanaerobacter …
applications as biocatalysts. Secondary ADHs from Thermoanaerobacter …
Expanding the Substrate Specificity of Thermoanaerobacter pseudoethanolicus Secondary Alcohol Dehydrogenase by a Dual Site Mutation
Here, we report the asymmetric reduction of selected phenyl‐ring‐containing ketones by
various single‐and dual‐site mutants of Thermoanaerobacter pseudoethanolicus secondary …
various single‐and dual‐site mutants of Thermoanaerobacter pseudoethanolicus secondary …
Biocatalytic racemization employing TeSADH: substrate scope and organic solvent compatibility for dynamic kinetic resolution
Racemization in combination with a kinetic resolution is the base for a dynamic kinetic
resolution (DKR). Biocatalytic racemization was successfully performed for a broad scope of …
resolution (DKR). Biocatalytic racemization was successfully performed for a broad scope of …
Enantiocomplementary Asymmetric Reduction of 2–Haloacetophenones Using TeSADH: Synthesis of Enantiopure 2-Halo-1-arylethanols
Enantiopure 2-halo-1-arylethanols are essential precursors for the synthesis of
pharmaceuticals, agrochemicals, and fine chemicals. This study investigates the asymmetric …
pharmaceuticals, agrochemicals, and fine chemicals. This study investigates the asymmetric …