Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control
J Bukh - Journal of hepatology, 2016 - Elsevier
The discovery of hepatitis C virus (HCV) in 1989 permitted basic research to unravel critical
components of a complex life cycle for this important human pathogen. HCV is a highly …
components of a complex life cycle for this important human pathogen. HCV is a highly …
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
Background Only 15 to 20 percent of patients with chronic hepatitis C have a sustained
virologic response to interferon therapy. We compared the efficacy and safety of …
virologic response to interferon therapy. We compared the efficacy and safety of …
[HTML][HTML] Viruses and interferon: a fight for supremacy
MG Katze, Y He, M Gale - Nature Reviews Immunology, 2002 - nature.com
The action of interferons (IFNs) on virus-infected cells and surrounding tissues elicits an
antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated …
antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated …
[HTML][HTML] The natural history of hepatitis C virus (HCV) infection
SL Chen, TR Morgan - International journal of medical sciences, 2006 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and
hepatocellular carcinoma, as well as the most common indication for liver transplantation in …
hepatocellular carcinoma, as well as the most common indication for liver transplantation in …
[PDF][PDF] Course and outcome of hepatitis C
JH Hoofnagle - Hepatology, 2002 - Wiley Online Library
The hepatitis C virus (HCV) is a small enveloped RNA virus belonging to the family
flaviviridae and genus hepacivirus. The HCV RNA genome is 9,600 nucleotides in length …
flaviviridae and genus hepacivirus. The HCV RNA genome is 9,600 nucleotides in length …
Risk and management of blood-borne infections in health care workers
EM Beltrami, IT Williams, CN Shapiro… - Clinical microbiology …, 2000 - Am Soc Microbiol
Exposure to blood-borne pathogens poses a serious risk to health care workers (HCWs). We
review the risk and management of human immunodeficiency virus (HIV), hepatitis B virus …
review the risk and management of human immunodeficiency virus (HIV), hepatitis B virus …
Diagnosis and monitoring of hepatic injury. I. Performance characteristics of laboratory tests
DR Dufour, JA Lott, FS Nolte, DR Gretch… - Clinical …, 2000 - academic.oup.com
Purpose: To review information on performance characteristics for tests that are commonly
used to identify acute and chronic hepatic injury. Data Sources and Study Selection: A …
used to identify acute and chronic hepatic injury. Data Sources and Study Selection: A …
Efficient initiation of HCV RNA replication in cell culture
KJ Blight, AA Kolykhalov, CM Rice - Science, 2000 - science.org
Hepatitis C virus (HCV) infection is a global health problem affecting an estimated 170
million individuals worldwide. We report the identification of multiple independent adaptive …
million individuals worldwide. We report the identification of multiple independent adaptive …
Clinical significance of hepatitis C virus genotypes
NN Zein - Clinical microbiology reviews, 2000 - Am Soc Microbiol
On the basis of phylogenetic analysis of nucleotide sequences, multiple genotypes and
subtypes of hepatitis C virus (HCV) have been identified. Characterization of these genetic …
subtypes of hepatitis C virus (HCV) have been identified. Characterization of these genetic …