Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

SF3B1 hotspot mutations are associated with a poor prognosis in several tumor types and
lead to global disruption of canonical splicing. Through synthetic lethal drug screens, we …

Fluorouracil (5-FU) is a key component of chemotherapy for colorectal cancer (CRC). 5-FU
efficacy is established by intracellular levels of folate cofactors and DNA damage repair …

The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse
biosynthetic functions. While some tumors can synthesize serine de novo, others are …

RNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of
dysregulated splicing in hematopoiesis remains unclear. To overcome technical limitations …

Summary Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the
integrated stress response (ISR) that enables cell survival under nutrient stress. The …

Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a
favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 …

Myelodysplastic syndrome (MDS) is a clonal hematopoietic neoplasm characterized by
bone marrow dysplasia, failure of hematopoiesis and variable risk of progression to acute …

Although endometrial cancer is the most common cancer of the female reproductive tract, we
have little understanding of what controls endometrial cancer beyond the transcriptional …