Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

All spiders produce protein-based biopolymer fibres that we call silk. The most studied of
these silks is spider dragline silk, which is very tough and relatively abundant compared with …

The envelope (E) protein of the SARS-CoV-2 virus forms cation-conducting channels in the
endoplasmic reticulum Golgi intermediate compartment (ERGIC) of infected cells. The …

Publisher Summary This chapter discusses the integrated methods for the construction of
three-dimensional models and computational probing of structure–function relations in G …

We have developed an automatic algorithm STRIDE for protein secondary structure
assignment from atomic coordinates based on the combined use of hydrogen bond energy …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

The Hsp90 chaperone is required for the activation of several families of eukaryotic protein
kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a …

To study the influence of proline residues on three-dimensional structure, an analysis has
been made of all proline residues and their local conformations extracted from the …

X-ray diffraction was one of the early methods to be used in solving protein conformation.
The technique can give the atomic coordinates of the protein components and therefore …

Publisher Summary Hydration can be considered a process of adding water incrementally to
dry protein, until a level of hydration is reached beyond which further addition of water …