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Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons
The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …
neurons into 'cell types'. Historically, such cell types were broadly defined by their …
The action potential in mammalian central neurons
BP Bean - Nature Reviews Neuroscience, 2007 - nature.com
The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …
conductances in the cell membrane, yet mammalian central neurons typically express more …
Distinct neural circuits for the formation and retrieval of episodic memories
The formation and retrieval of a memory is thought to be accomplished by activation and
reactivation, respectively, of the memory-holding cells (engram cells) by a common set of …
reactivation, respectively, of the memory-holding cells (engram cells) by a common set of …
High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor
Accurate optical reporting of electrical activity in genetically defined neuronal populations is
a long-standing goal in neuroscience. We developed Accelerated Sensor of Action …
a long-standing goal in neuroscience. We developed Accelerated Sensor of Action …
Pyramidal neurons: dendritic structure and synaptic integration
Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …
the pyramidal shape of their soma. They are found in several regions of the CNS and …
Dissociable structural and functional hippocampal outputs via distinct subiculum cell classes
The mammalian hippocampus, comprised of serially connected subfields, participates in
diverse behavioral and cognitive functions. It has been postulated that parallel circuitry …
diverse behavioral and cognitive functions. It has been postulated that parallel circuitry …
[HTML][HTML] Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking
Neurexins are essential presynaptic cell adhesion molecules that are linked to
schizophrenia and autism and are subject to extensive alternative splicing. Here, we used a …
schizophrenia and autism and are subject to extensive alternative splicing. Here, we used a …
Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment
For each environment a rodent has explored, its hippocampus contains a map consisting of
a unique subset of neurons, called place cells, that have spatially tuned spiking there, with …
a unique subset of neurons, called place cells, that have spatially tuned spiking there, with …
[HTML][HTML] Hippocampal pyramidal neurons comprise two distinct cell types that are countermodulated by metabotropic receptors
Relating the function of neuronal cell types to information processing and behavior is a
central goal of neuroscience. In the hippocampus, pyramidal cells in CA1 and the subiculum …
central goal of neuroscience. In the hippocampus, pyramidal cells in CA1 and the subiculum …
Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons
In brain, signaling mediated by cell adhesion molecules defines the identity and functional
properties of synapses. The specificity of presynaptic and postsynaptic interactions that is …
properties of synapses. The specificity of presynaptic and postsynaptic interactions that is …