Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections

P Zimmermann, N Curtis - Archives of disease in childhood, 2021 - adc.bmj.com
In contrast to other respiratory viruses, children have less severe symptoms when infected
with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this …

The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections

J Machhi, J Herskovitz, AM Senan, D Dutta… - Journal of neuroimmune …, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

OV Swann, KA Holden, L Turtle, L Pollock, CJ Fairfield… - bmj, 2020 - bmj.com
Objective To characterise the clinical features of children and young people admitted to
hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS …

Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children

P Zimmermann, N Curtis - The Pediatric infectious disease journal, 2020 - journals.lww.com
Coronaviruses (CoVs) are a large family of enveloped, single-stranded, zoonotic RNA
viruses. Four CoVs commonly circulate among humans: HCoV2-229E,-HKU1,-NL63 and …

The many faces of the anti-COVID immune response

SA Vardhana, JD Wolchok - Journal of Experimental Medicine, 2020 - rupress.org
Disclosures: SA Vardhana reported personal fees from Immunai and personal fees from
ADC Therapeutics outside the submitted work; in addition, SA Vardhana had a patent to …

COVID-19 in children, pregnancy and neonates: a review of epidemiologic and clinical features

P Zimmermann, N Curtis - The Pediatric infectious disease journal, 2020 - journals.lww.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
spread rapidly across the globe. In contrast to initial reports, recent studies suggest that …

A well infant with coronavirus disease 2019 with high viral load

K Kam, CF Yung, L Cui, R Tzer Pin Lin… - Clinical Infectious …, 2020 - academic.oup.com
A well 6-month-old infant with coronavirus disease 2019 (COVID-19) had persistently
positive nasopharyngeal swabs up to day 16 of admission. This case highlights the …

Severe acute respiratory syndrome: historical, epidemiologic, and clinical features

DSC Hui, A Zumla - Infectious Disease Clinics, 2019 - id.theclinics.com
Over the past 2 decades 2 previously unknown coronaviruses (CoVs), the severe acute
respiratory syndrome CoV (SARS-CoV) and the Middle East respiratory syndrome CoV …

Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China

Y Yang, QB Lu, MJ Liu, YX Wang, AR Zhang, N Jalali… - medrxiv, 2020 - medrxiv.org
Background The ongoing outbreak of the 2019 novel coronavirus (2019-nCoV) in China has
led to the declaration of Public Health Emergency of International Concern by the World …