[HTML][HTML] Diabetes mellitus—Progress and opportunities in the evolving epidemic
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an
excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome …
excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome …
Untangling the genetics of beta cell dysfunction and death in type 1 diabetes
Abstract Type 1 diabetes (T1D) is a complex multi-system disease which arises from both
environmental and genetic factors, resulting in the destruction of insulin-producing …
environmental and genetic factors, resulting in the destruction of insulin-producing …
Genetic basis of early onset and progression of type 2 diabetes in South Asians
S Hodgson, A Williamson, M Bigossi, D Stow… - Nature Medicine, 2024 - nature.com
South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass
index (BMI). However, reasons for this are poorly understood because genetic research is …
index (BMI). However, reasons for this are poorly understood because genetic research is …
Functional genomics of human skeletal development and the patterning of height heritability
Underlying variation in height are regulatory changes to chondrocytes, cartilage cells
comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation …
comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation …
Genetic insights into global heterogeneity of type 2 diabetes
MS Udler - Nature Medicine, 2025 - nature.com
Genetic insights into global heterogeneity of type 2 diabetes | Nature Medicine Skip to main
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Multi-omics characterization of type 2 diabetes associated genetic variation
Discerning the mechanisms driving type 2 diabetes (T2D) pathophysiology from genome-
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …
Type 2 diabetes across populations of different ancestry: deconstructing the genomic landscape
G Xourafa, C Herder, M Roden - Signal Transduction and Targeted …, 2024 - nature.com
In a recent study published in Nature Medicine, Smith and colleagues used data from 1.4
million individuals across 37 genome-wide association studies (GWAS) reflecting different …
million individuals across 37 genome-wide association studies (GWAS) reflecting different …
Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 …
G Yu, CHT Tam, CKP Lim, M Shi, ESH Lau, R Ozaki… - Diabetologia, 2024 - Springer
Methods We employed newly developed type 2 diabetes hard-clustering and soft-clustering
pathway-specific polygenic risk scores (psPRSs) to characterise individual genetic …
pathway-specific polygenic risk scores (psPRSs) to characterise individual genetic …
A Research Roadmap to Address the Heterogeneity of Diabetes and Advance Precision Medicine
The current classification of diabetes had its genesis over 85 years ago, when individuals
with diabetes were first subclassified into insulin sensitive and insulin insensitive states …
with diabetes were first subclassified into insulin sensitive and insulin insensitive states …