Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an
excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome …

Abstract Type 1 diabetes (T1D) is a complex multi-system disease which arises from both
environmental and genetic factors, resulting in the destruction of insulin-producing …

Background Data to support individualised choice of optimal glucose-lowering therapy are
scarce for people with type 2 diabetes. We aimed to establish whether routinely available …

Underlying variation in height are regulatory changes to chondrocytes, cartilage cells
comprising long-bone growth plates. Currently, we lack knowledge on epigenetic regulation …

South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass
index (BMI). However, reasons for this are poorly understood because genetic research is …

Genetic insights into global heterogeneity of type 2 diabetes | Nature Medicine Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Discerning the mechanisms driving type 2 diabetes (T2D) pathophysiology from genome-
wide association studies (GWAS) remains a challenge. To this end, we integrated omics …

In a recent study published in Nature Medicine, Smith and colleagues used data from 1.4
million individuals across 37 genome-wide association studies (GWAS) reflecting different …

Methods We employed newly developed type 2 diabetes hard-clustering and soft-clustering
pathway-specific polygenic risk scores (psPRSs) to characterise individual genetic …