Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
TGFβ signalling in context
J Massagué - Nature reviews Molecular cell biology, 2012 - nature.com
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1
Epithelial-to-mesenchymal transitions (EMTs) are phenotypic plasticity processes that confer
migratory and invasive properties to epithelial cells during development, wound-healing …
migratory and invasive properties to epithelial cells during development, wound-healing …
Transcriptional control by the SMADs
CS Hill - Cold Spring Harbor perspectives in biology, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by
initiating new programs of gene expression. The best understood signal transducers for …
initiating new programs of gene expression. The best understood signal transducers for …
Endogenous retroviruses function as species-specific enhancer elements in the placenta
The mammalian placenta is remarkably distinct between species, suggesting a history of
rapid evolutionary diversification. To gain insight into the molecular drivers of placental …
rapid evolutionary diversification. To gain insight into the molecular drivers of placental …
The p53 family coordinates Wnt and nodal inputs in mesendodermal differentiation of embryonic stem cells
In this study, we outline a regulatory network that involves the p53 tumor suppressor family
and the Wnt pathway acting together with the TGF-β pathway in mesendodermal …
and the Wnt pathway acting together with the TGF-β pathway in mesendodermal …
Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells
T Faial, AS Bernardo, S Mendjan, E Diamanti… - …, 2015 - journals.biologists.com
The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and
lineage specification in vertebrates. Despite its wide use and importance in stem cell and …
lineage specification in vertebrates. Despite its wide use and importance in stem cell and …
[HTML][HTML] TGF-β signaling to chromatin: how Smads regulate transcription during self-renewal and differentiation
T Gaarenstroom, CS Hill - Seminars in cell & developmental biology, 2014 - Elsevier
Ligands of the TGF-β superfamily (including the TGF-βs, Nodal and BMPs) play instructive
roles during embryonic development. This is achieved by regulation of genes important for …
roles during embryonic development. This is achieved by regulation of genes important for …
TGF-β family signaling in stem cells
M Sakaki-Yumoto, Y Katsuno, R Derynck - Biochimica et Biophysica Acta …, 2013 - Elsevier
BACKGROUND: The diversity of cell types and tissue types that originate throughout
development derives from the differentiation potential of embryonic stem cells and somatic …
development derives from the differentiation potential of embryonic stem cells and somatic …
FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis
FOXO transcription factors are central regulators of longevity from worms to humans.
FOXO3, the FOXO isoform associated with exceptional human longevity, preserves adult …
FOXO3, the FOXO isoform associated with exceptional human longevity, preserves adult …