Although mathematical relationships can be proven by deductive logic, biological
relationships can only be inferred from empirical observations. This is a distinct …

Association methods based on linkage disequilibrium (LD) offer a promising approach for
detecting genetic variations that are responsible for complex human diseases. Although …

In complex disease studies, it is crucial to perform multipoint linkage analysis with many
markers and to use robust nonparametric methods that take account of all pedigree …

A predisposition for thoracic aortic aneurysms leading to acute aortic dissections can be
inherited in families in an autosomal dominant manner. Genome-wide linkage analysis of …

Prior evidence has supported the existence of multiple susceptibility genes for
schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we …

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS or SACS) is an early
onset neurodegenerative disease with high prevalence (carrier frequency 1/22) in the …

Background: Majeed syndrome is an autosomal recessive, autoinflammatory disorder
characterised by chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic …

Six extended dyslexic families with at least four affected individuals were genotyped with
markers in three chromosomal regions: 6p23-p21. 3, 15pter-qter, and 16pter-qter. Five …

HaploPainter is a user-friendly pedigree-drawing application with special features for easy
visualization of complex haplotype information. It has been developed to facilitate gene …

Autism is characterized by impairments in reciprocal social interaction and communication,
and restricted and stereotyped patterns of interests and activities. Developmental difficulties …