Map** the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

Lysine acylations are ubiquitous and structurally diverse post-translational modifications that
vastly expand the functional heterogeneity of the human proteome. Hence, the targeted …

Honokiol is a natural product with an interesting array of biological effects, including
significant anti-tumor properties. However, full exploration of its therapeutic potential is …

Chemical proteomics enables the global analysis of small molecule-protein interactions in
native biological systems and has emerged as a versatile approach for ligand discovery …

A concise and collective biomimetic synthesis of myrtucommulones KL and N, as well as
callistiviminenes FH, has been achieved utilizing a mild Me 2 AlCl-mediated hetero-Diels …

(+)/(−)-Xanthrysol A (1), an enantiomeric pair of novel macrocyclic meroterpenoids, along
with three enantiomeric pairs of biogenetically related meroterpenoids (+)/(−)-xanthrysols B …

Map** the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based chemoproteomics. Achieving this ambitious …