The incorporation of heterocyclic moieties into the standard chemical structure with a
biologically active scaffold has become of crucial practice for the construction of …

Diabetes Mellitus (DM) is the fastest growing metabolic disorder affecting about 387 million
people across the globe and is estimated to affect 592 million people by year 2030. The …

In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Cardiovascular diseases are the leading cause of death affecting 17.3 million people across
the globe and are estimated to affect 23.3 million people by year 2030. In recent years …

DNA replication and repair are complex processes accomplished by the concerted action of
a network of enzymes and proteins. DNA ligases play a crucial role in these processes by …

Although a diverse range of chemical entities offering striking therapeutic potential against
urease enzyme has been reported, the key challenges (toxicity and safety) associated with …

There is currently an urgent need for new anthelmintic agents due to increasing resistance
to the limited available drugs. The chalcone scaffold is a privileged structure for develo** …

Aminothiazole organic compounds have diverse biological applications. Herein we report
the synthesis of two aminothiazole derivatives: 4-(biphenyl-4-yl) thiazol-2-amine (1) and 4 …

The structural motifs of chalcones, flavones, and triazoles with varied substitutions have
been studied for the antimalarial activity. In this study, 25 novel derivatives of chalcone and …

Lymphatic filariasis and onchocerciasis are common filarial diseases caused by filarial
worms, which co-habit symbiotically with the Wolbachia organism. One good treatment …