Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
The fine-tuned crosstalk between lysine acetylation and the circadian rhythm
H Jiang, X Wang, J Ma, G Xu - Biochimica et Biophysica Acta (BBA)-Gene …, 2023 - Elsevier
Circadian rhythm is a roughly 24-h wake and sleep cycle that almost all of the organisms on
the earth follow when they execute their biological functions and physiological activities. The …
the earth follow when they execute their biological functions and physiological activities. The …
Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction
CM François, T Pihl, M Dunoyer de Segonzac… - Nature …, 2023 - nature.com
The molecular mechanisms connecting cellular metabolism with differentiation remain
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …
N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase
MA Eldeeb, MA Ragheb - Current Genetics, 2020 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by a
gradual loss of a specific group of dopaminergic neurons in the substantia nigra. Importantly …
gradual loss of a specific group of dopaminergic neurons in the substantia nigra. Importantly …
N-terminal acetylation can stabilize proteins independent of their ubiquitination
B van de Kooij, E de Vries, RW Rooswinkel… - Scientific Reports, 2023 - nature.com
The majority of proteins in mammalian cells are modified by covalent attachment of an acetyl-
group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested …
group to the N-terminus (Nt-acetylation). Paradoxically, Nt-acetylation has been suggested …
One‐carbon metabolism, folate, zinc and translation
A Danchin, A Sekowska, C You - Microbial Biotechnology, 2020 - Wiley Online Library
The translation process, central to life, is tightly connected to the one‐carbon (1‐C)
metabolism via a plethora of macromolecule modifications and specific effectors. Using …
metabolism via a plethora of macromolecule modifications and specific effectors. Using …
Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways
Among the most salient features that underpin the development of aging-related
neurodegenerative disorders are the accumulation of protein aggregates and the decrease …
neurodegenerative disorders are the accumulation of protein aggregates and the decrease …
Fine‐tuning ER‐phagy by post‐translational modifications
Autophagy functions in both selective and non‐selective ways to maintain cellular
homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy …
homeostasis. Endoplasmic reticulum autophagy (ER‐phagy) is a subclass of autophagy …
MicroRNA-372-3p predicts response of TACE patients treated with doxorubicin and enhances chemosensitivity in hepatocellular carcinoma
Background: Identification of factors to detect and improve chemotherapy-response in
cancer is the main concern. microRNA-372-3p (miR-372-3p) has been demonstrated to play …
cancer is the main concern. microRNA-372-3p (miR-372-3p) has been demonstrated to play …
[HTML][HTML] Effect of Glycosylation on the Enzymatic Degradation of D-Amino Acid-Containing Peptides
S Cui, Z **, T Yu, C Guo, Y He, Y Kan, L Yan, L Wu - Molecules, 2025 - mdpi.com
The accumulation of D-amino acid-containing peptides is associated with age-related
diseases such as Alzheimer's disease and cataracts, while glycosylation is an important …
diseases such as Alzheimer's disease and cataracts, while glycosylation is an important …