The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

Introduction: The complement system is essential for an adequate immune response. Much
attention has been given to the role of complement in disease. However, to better …

Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic
inflammatory bowel disease (IBD), such as Crohn disease and ulcerative colitis. In early …

The complement system is pivotal in host defense but also contributes to tissue injury in
several diseases. The assembly of C3 convertases (C4b2a and C3bBb) is a prerequisite for …

The complement system is the other major proteolytic cascade in the blood of vertebrates
besides the coagulation–fibrinolytic system. Among the three main activation routes of …

• Introduction• Methods to study and modify the alternative pathway‐Inhibition by
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …

Over the past decade, there has been a substantial increase in interest in the immune
system and the role it plays in the regulation of disease susceptibility, giving rise to the field …

The lectin pathway of complement activation is an important component of the innate
immune defense. The initiation complexes of the lectin pathway consist of a recognition …

The human collectin, mannose‐binding lectin (MBL), is an important protein of the humoral
innate immune system. With multiple carbohydrate‐recognition domains, it is able to bind to …