The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Microtubule motors play key roles in cellular functions, such as transport, mitosis and cell
motility. Fueled by ATP hydrolysis, they convert chemical energy into mechanical work …

The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …

During mitosis, motor proteins and microtubule-associated protein organize the spindle
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …

Within the mitotic spindle, kinesin motors cross-link and slide overlap** microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …

At each cell division, the spindle self-organizes from microtubules and motors. In human
spindles, the motors dynein and Eg5 generate contractile and extensile stress, respectively …

Centrosome amplification is a hallmark of cancer, and centrosome clustering is essential for
cancer cell survival. The mitotic kinesin HSET is an essential contributor to this process …

Accurate chromosome segregation during cell division relies on coordinated actions of
microtubule (MT)-based motor proteins in the mitotic spindle. Kinesin-14 motors play vital …

Over the last 25 years, extensive progress has been made in develo** a range of
nanotechnological applications where cytoskeletal filaments and molecular motors are key …

Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to
its load and usually move towards microtubule minus ends, whilst most other kinesins have …