Hydroamination, the addition of an N–H bond across a C–C multiple bond, is a reaction with
a great synthetic potential. Important advances have been made in the last decades …

Abstract The concept of 1, 3‐dipolar cycloadditions was presented by Rolf Huisgen 60 years
ago. Previously unknown reactive intermediates, for example azomethine ylides, were …

Energy decomposition analysis (EDA) is an important class of methods to explore the nature
of interaction between fragments in a chemical system. It can decompose the interaction …

Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Challenges in quantifying how force affects bond formation have hindered the widespread
adoption of mechanochemistry. We used parallel tip-based methods to determine reaction …

A growing number of organopnictogen redox catalytic methods have emerged—especially
within the past 10 years—that leverage the plentiful reversible two-electron redox chemistry …

Computational chemistry provides a versatile toolbox for studying mechanistic details of
catalytic reactions and holds promise to deliver practical strategies to enable the rational in …

Site-and enantioselective incorporation of deuterium into organic compounds is of broad
interest in organic synthesis, especially within the pharmaceutical industry. While catalytic …

Understanding chemical reactivity through the use of state-of-the-art computational
techniques enables chemists to both predict reactivity and rationally design novel reactions …

The cycloaddition reaction involving bicyclo [1.1. 0] butanes (BCBs) offers a versatile and
efficient synthetic platform for producing C (sp3)‐rich rigid bridged ring scaffolds, which act …