Epigenetic regulation refers to the alteration of gene expression independent of changes in
DNA sequence. It involves chemical modifications such as DNA methylation, histone …

Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Acute myeloid leukemia (AML) is a highly aggressive hematologic cancer with poor survival
across a broad range of molecular subtypes. Development of efficacious and well-tolerable …

Transformation to diffuse large B-cell lymphoma (DLBCL) is a recognized, but unpredictable,
clinical inflection point in the natural history of indolent lymphomas. Large retrospective …

Simple Summary Medulloblastoma is the most prevalent intracerebellar pediatric brain
tumor, accounting for approximately 20% of all childhood brain tumors and over 60% of …

Abstract Protein Arginine Methyltransferases (PRMTs) are a family of enzymes regulating
protein arginine methylation, which is a post-translational modification crucial for various …

Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma, and patients
who relapse on targeted therapies have poor prognosis. Protein arginine methyltransferase …

Mantle cell lymphoma (MCL) is an incurable B-cell malignancy that comprises up to 6% of
non-Hodgkin lymphomas diagnosed annually and is associated with a poor prognosis. The …

L-arginine is the most nitrogen-rich amino acid, acting as a key precursor for the synthesis of
nitrogen-containing metabolites and an essential intermediate in the clearance of excess …

Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed
dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond …