Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
The glymphatic system: implications for drugs for central nervous system diseases
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …
known as the glymphatic system has grown. According to the glymphatic system concept …
Cerebrospinal fluid flow
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …
through the brain transports not only those water-like fluids but also any solutes they carry …
Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …
The interconnected causes and consequences of sleep in the brain
Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance
The accumulation of metabolic waste is a leading cause of numerous neurological
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …
disorders, yet we still have only limited knowledge of how the brain performs self-cleansing …
A daily temperature rhythm in the human brain predicts survival after brain injury
Patients undergo interventions to achieve a 'normal'brain temperature; a parameter that
remains undefined for humans. The profound sensitivity of neuronal function to temperature …
remains undefined for humans. The profound sensitivity of neuronal function to temperature …
Impact of sleep duration on executive function and brain structure
Sleep is essential for life, including daily cognitive processes, yet the amount of sleep
required for optimal brain health as we grow older is unclear. Poor memory and increased …
required for optimal brain health as we grow older is unclear. Poor memory and increased …
Brain clearance is reduced during sleep and anesthesia
It has been suggested that the function of sleep is to actively clear metabolites and toxins
from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we …
from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we …