BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …

The exceptional mechanical properties of the load-bearing connection of tendon to bone
rely on an intricate interplay of its biomolecular composition, microstructure and …

Successful engineering of load-bearing tissues requires recapitulation of their complex
mechanical functions. Given the intimate relationship between function and form, biomimetic …

Despite the critical role tendons play in transmitting loads throughout the musculoskeletal
system, little is known about the microstructural mechanisms underlying their mechanical …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

BACKGROUND: Complex loading develops in multiple spinal motions and in the case of
hyperflexion is known to cause intervertebral disc (IVD) injury. Few studies have examined …

Despite considerable efforts to develop cellular, molecular, and structural repair strategies
and restore intervertebral disk function after injury, the basic biology underlying …

Smart anti-impact materials are desirable for personal protection and industrial security.
However, they often suffer from poor performance control and inherent stability issues. Here …

The primary function of the disc is mechanical; therefore, degenerative changes in disc
mechanics and the interactions between the annulus fibrosus (AF) and nucleus pulposus …