Genetics of wellbeing and its components satisfaction with life, happiness, and quality of life: A review and meta-analysis of heritability studies
M Bartels - Behavior genetics, 2015 - Springer
Wellbeing is a major topic of research across several disciplines, reflecting the increasing
recognition of its strong value across major domains in life. Previous twin-family studies …
recognition of its strong value across major domains in life. Previous twin-family studies …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …
polygenic architecture or its genetic relationship with other disorders. To discover loci …
Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
Metabolomics examines the small molecules involved in cellular metabolism. Approximately
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
50% of total phenotypic differences in metabolite levels is due to genetic variance, but …
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
Little is known about the genetic architecture of traits affecting educational attainment other
than cognitive ability. We used genomic structural equation modeling and prior genome …
than cognitive ability. We used genomic structural equation modeling and prior genome …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a …
because of limitations on sample size in previous studies. Subjective well-being, a …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Multivariate genome-wide analyses of the well-being spectrum
We introduce two novel methods for multivariate genome-wide-association meta-analysis
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
(GWAMA) of related traits that correct for sample overlap. A broad range of simulation …
The Netherlands twin register: longitudinal research based on twin and twin-family designs
L Ligthart, CEM van Beijsterveldt… - Twin Research and …, 2019 - cambridge.org
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and
their parents, siblings, spouses and other family members participate. Here we describe the …
their parents, siblings, spouses and other family members participate. Here we describe the …
[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …
birth complications. Many maternal obesity-related traits are observationally associated with …
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
novel insights into disease pathogenesis. We did an epigenome-wide association study to …