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Cone-shaped HIV-1 capsids are transported through intact nuclear pores
Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …
uncoating and nuclear import of the viral genome are critical for productive infection. The …
Host factors mediating HIV-1 replication
Human immunodeficiency virus type 1 (HIV-1) infection is the leading cause of death
worldwide in adults attributable to infectious diseases. Although the majority of infections are …
worldwide in adults attributable to infectious diseases. Although the majority of infections are …
HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication
The lifecycle of retroviruses and retrotransposons includes a reverse transcription step,
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
Cell-specific CRISPR–Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins
MD Hoffmann, S Aschenbrenner, S Grosse… - Nucleic acids …, 2019 - academic.oup.com
The rapid development of CRISPR–Cas technologies brought a personalized and targeted
treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise …
treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise …
Pre-arrayed pan-AAV peptide display libraries for rapid single-round screening
Display of short peptides on the surface of adeno-associated viruses (AAVs) is a powerful
technology for the generation of gene therapy vectors with altered cell specificities and/or …
technology for the generation of gene therapy vectors with altered cell specificities and/or …
Systematic approaches towards the development of host-directed antiviral therapeutics
Since the onset of antiviral therapy, viral resistance has compromised the clinical value of
small-molecule drugs targeting pathogen components. As intracellular parasites, viruses …
small-molecule drugs targeting pathogen components. As intracellular parasites, viruses …
Relevance of assembly-activating protein for adeno-associated virus vector production and capsid protein stability in mammalian and insect cells
S Grosse, M Penaud-Budloo, AK Herrmann… - Journal of …, 2017 - Am Soc Microbiol
The discovery that adeno-associated virus 2 (AAV2) encodes an eighth protein, called
assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology …
assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology …
Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines
As the only mammalian Argonaute protein capable of directly cleaving mRNAs in a small
RNA-guided manner, Argonaute-2 (Ago2) is a keyplayer in RNA interference (RNAi) …
RNA-guided manner, Argonaute-2 (Ago2) is a keyplayer in RNA interference (RNAi) …
Detailed characterization of early HIV-1 replication dynamics in primary human macrophages
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral
replication appears to be delayed in these cells compared to lymphocytes; however, little is …
replication appears to be delayed in these cells compared to lymphocytes; however, little is …