Cone-shaped HIV-1 capsids are transported through intact nuclear pores
V Zila, E Margiotta, B Turoňová, TG Müller, CE Zimmerli… - Cell, 2021 - cell.com
Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …
uncoating and nuclear import of the viral genome are critical for productive infection. The …
Host factors mediating HIV-1 replication
BM Friedrich, N Dziuba, G Li, MA Endsley, JL Murray… - Virus research, 2011 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) infection is the leading cause of death
worldwide in adults attributable to infectious diseases. Although the majority of infections are …
worldwide in adults attributable to infectious diseases. Although the majority of infections are …
HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication
D **, K Musier-Forsyth - Journal of Biological Chemistry, 2019 - jbc.org
The lifecycle of retroviruses and retrotransposons includes a reverse transcription step,
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
Cell-specific CRISPR–Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins
MD Hoffmann, S Aschenbrenner, S Grosse… - Nucleic acids …, 2019 - academic.oup.com
The rapid development of CRISPR–Cas technologies brought a personalized and targeted
treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise …
treatment of genetic disorders into closer reach. To render CRISPR-based therapies precise …
Pre-arrayed pan-AAV peptide display libraries for rapid single-round screening
K Börner, E Kienle, LY Huang, J Weinmann, A Sacher… - Molecular therapy, 2020 - cell.com
Display of short peptides on the surface of adeno-associated viruses (AAVs) is a powerful
technology for the generation of gene therapy vectors with altered cell specificities and/or …
technology for the generation of gene therapy vectors with altered cell specificities and/or …
Relevance of assembly-activating protein for adeno-associated virus vector production and capsid protein stability in mammalian and insect cells
S Grosse, M Penaud-Budloo, AK Herrmann… - Journal of …, 2017 - journals.asm.org
The discovery that adeno-associated virus 2 (AAV2) encodes an eighth protein, called
assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology …
assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology …
Systematic approaches towards the development of host-directed antiviral therapeutics
A Prussia, P Thepchatri, JP Snyder… - International journal of …, 2011 - mdpi.com
Since the onset of antiviral therapy, viral resistance has compromised the clinical value of
small-molecule drugs targeting pathogen components. As intracellular parasites, viruses …
small-molecule drugs targeting pathogen components. As intracellular parasites, viruses …
Detailed characterization of early HIV-1 replication dynamics in primary human macrophages
DA Bejarano, MC Puertas, K Börner, J Martinez-Picado… - Viruses, 2018 - mdpi.com
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral
replication appears to be delayed in these cells compared to lymphocytes; however, little is …
replication appears to be delayed in these cells compared to lymphocytes; however, little is …
The virus as metabolic engineer
ND Maynard, MV Gutschow, EW Birch… - Biotechnology …, 2010 - Wiley Online Library
Recent genome‐wide screens of host genetic requirements for viral infection have
reemphasized the critical role of host metabolism in enabling the production of viral …
reemphasized the critical role of host metabolism in enabling the production of viral …