Adult articular cartilage exhibits little capacity for intrinsic repair, and thus even minor injuries
or lesions may lead to progressive damage and osteoarthritic joint degeneration, resulting in …

Background Autologous chondrocyte implantation (ACI) is an established and well-accepted
procedure for the treatment of localised full-thickness cartilage defects of the knee. Methods …

Computational mechanics has been advanced in every area of orthopedic biomechanics.
The objective of this paper is to provide a general review of the computational models used …

Focal cartilage lesions can proceed to severe osteoarthritis or remain unaltered even for
years. A method to identify high risk defects would be of utmost importance to guide clinical …

Articular cartilages and menisci are generally considered to be elastic in the published
human knee models, and thus the fluid-flow dependent response of the knee has not been …

Osteoarthritis (OA) is a degenerative disease that affects the synovial joints, especially the
knee joint, diminishing the ability of patients to perform daily physical activities …

Advances in computational mechanics, constitutive modeling, and techniques for subject-
specific modeling have opened the door to patient-specific simulation of the relationships …

Purpose Surgical treatment options for the management of focal chondral and
osteochondral lesions in the knee include biological solutions and focal metal implants. A …

Articular cartilage experiences significant mechanical loads during daily activities. Healthy
cartilage provides the capacity for load bearing and regulates the mechanobiological …

Focal damage to articular cartilage is common in arthroscopy patients, and may contribute to
progressive tissue degeneration by altering the local mechanical environment. The effects of …