Childhood obesity, hypothalamic inflammation, and the onset of puberty: A narrative review

AM Tzounakou, G Stathori, G Paltoglou, G Valsamakis… - Nutrients, 2024 - mdpi.com
The onset of puberty, which is under the control of the hypothalamic–pituitary–gonadal
(HPG) axis, is influenced by various factors, including obesity, which has been associated …

Sex as a determinant of age-related changes in the brain

DE Burmistrov, SV Gudkov, C Franceschi… - International Journal of …, 2024 - mdpi.com
The notion of notable anatomical, biochemical, and behavioral distinctions within male and
female brains has been a contentious topic of interest within the scientific community over …

[HTML][HTML] Opposite changes in morphometric similarity of medial reward and lateral non-reward orbitofrontal cortex circuits in obesity

D Dong, X Chen, W Li, X Gao, Y Wang, F Zhou… - NeuroImage, 2024 - Elsevier
Obesity has a profound impact on metabolic health thereby adversely affecting brain
structure and function. However, the majority of previous studies used a single structural …

[HTML][HTML] Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: a randomized controlled trial

AC Koschker, B Warrings, C Morbach, F Seyfried… - Metabolism, 2023 - Elsevier
Objective Randomized evidence comparing the cardiovascular effects of surgical and
conservative weight management is lacking. Patients & methods In this single-center, open …

Bidirectional two-sample Mendelian randomization analyses support causal relationships between structural and diffusion imaging-derived phenotypes and the risk of …

Z Wang, X Yang, H Li, S Wang, Z Liu, Y Wang… - Translational …, 2024 - nature.com
Previous observational investigations suggest that structural and diffusion imaging-derived
phenotypes (IDPs) are associated with major neurodegenerative diseases; however …

The melanocortin‐4 receptor pathway and the emergence of precision medicine in obesity management

S Fansa, A Acosta - Diabetes, Obesity and Metabolism, 2024 - Wiley Online Library
Over the past few decades, there has been a global surge in the prevalence of obesity,
rendering it a globally recognized epidemic. Contrary to simply being a medical condition …

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

T Ester-Nacke, K Berti, R Veit, C Dannecker… - Scientific Reports, 2024 - nature.com
The hypothalamus is the key regulator for energy homeostasis and is functionally connected
to striatal and cortical regions vital for the inhibitory control of appetite. Hence, the ability to …

White adipose tissue distribution and amount are associated with increased white matter connectivity

L Okudzhava, S Schulz, E Fischi‐Gomez… - Human Brain …, 2024 - Wiley Online Library
Obesity represents a significant public health concern and is linked to various comorbidities
and cognitive impairments. Previous research indicates that elevated body mass index (BMI) …

[HTML][HTML] Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases

E Młynarska, P Jakubowska, W Frąk, A Gajewska… - Nutrients, 2024 - mdpi.com
Background/Objectives: Recent research highlights the growing interest in the impact of
nutrition on cognitive health and function in disease, as dietary habits are increasingly …

Overweight during development dysregulates cellular metabolism and critical genes that control food intake in the prefrontal cortex

SC de Andrade Silva, MDT De Lemos… - Physiology & …, 2024 - Elsevier
Backgrounds and aims Childhood obesity is increasing substantially across the world. The
World Obesity Federation (WOF) and World Health Organization (WHO) predicted that in …