The enteric nervous system (ENS) forms a versatile sensory system along the
gastrointestinal tract that interacts with most cell types in the bowel. Herein, we portray host …

Gastrointestinal (GI) comorbidities are common in individuals with mood and behavioral
dysfunction. Similarly, patients with GI problems more commonly suffer from co-morbid …

Hirschsprung disease (HSCR), one of several neurocristopathies in children, is
characterized by nerve loss in the large intestine and is mainly treated by surgery, which …

Neurocristopathies form a heterogeneous group of rare diseases caused by abnormal
development of neural crest cells. Heterogeneity of neurocristopathies directly relates to the …

Neurointestinal diseases represent a significant challenge in clinical management with
current palliative approaches failing to overcome disease and treatment-related morbidity …

Objective Hirschsprung disease (HSCR) is one of the common neurocristopathies in
children, which is associated with at least 20 genes and involves a complex regulatory …

Hirschsprung disease (HSCR) and its associated disorders (AD-HSCR) often result in
severe hypoperistalsis caused by enteric neuropathy, mesenchymopathy, and myopathy …

Background Hirschsprung's disease (HSCR) is a congenital gastrointestinal disorder,
characterized by enteric ganglia absence in part or entire of the colon, due to abnormal …

In our previous study, we showed that with increasing time in culture, the growth
characteristics of enteric neural crest-derived cells (ENCCs) change, and that the …

Objective. Neural crest stem cells (NCSCs) are prototypically migratory cells immigrating
from the dorsal neural tube to specific embryonic sites where they generate a variety of cell …