Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA
receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or …

The germinal center (GC) reaction is essential for long-lived humoral immunity. However,
molecular requirements for the induction of Bcl6, the master regulator for GC B cell …

Polycomb group proteins are evolutionary conserved chromatin‐modifying complexes,
essential for the regulation of developmental and cell‐identity genes. Polycomb‐mediated …

Abstract Polycomb repressive complexes-1 and-2 (PRC1 and 2) silence developmental
genes in a spatiotemporal manner during embryogenesis. How Polycomb group (PcG) …

ABSTRACT MEIS transcription factors are key regulators of embryonic development and
cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed …

Embryonic development requires the intricate balance between the expansion and
specialisation of defined cell types in time and space. The gene expression programmes …

Neuroblastoma is a tumour that arises from the sympathoadrenal lineage occurring
predominantly in children younger than five years. About half of the patients are diagnosed …

Vertebrate limb bud outgrowth and patterning is controlled by two instructive signaling
centers, the apical ectodermal ridge (AER) and the polarizing region in the posterior limb …

All-trans retinoic acid (ATRA), the biologically active form of vitamin A, is instrumental in
regulating the patterning and specification of the vertebrate embryo. Various animal models …