HIV infection
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …
Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy
NF McMyn, J Varriale, EJ Fray… - The Journal of …, 2023 - Am Soc Clin Investig
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses
HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …
considered" transcriptionally silent," but active viral gene expression may occur in some …
Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19
Objective To test the hypothesis that coronavirus disease 2019 (COVID-19) has an impact
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
on the CNS by measuring plasma biomarkers of CNS injury. Methods We recruited 47 …
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure,–.
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Curative strategies that target the reservoir are being tested, and require accurate, scalable …
Clinical use of lentiviral vectors
Viral vectors provide an efficient means for modification of eukaryotic cells, and their use is
now commonplace in academic laboratories and industry for both research and clinical …
now commonplace in academic laboratories and industry for both research and clinical …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
[HTML][HTML] Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …
Getting the “kill” into “shock and kill”: strategies to eliminate latent HIV
Y Kim, JL Anderson, SR Lewin - Cell host & microbe, 2018 - cell.com
Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …
treatment is life long. HIV persists during ART due to long-lived and proliferating latently …