A brief history of protein sorting prediction

H Nielsen, KD Tsirigos, S Brunak, G von Heijne - The protein journal, 2019 - Springer
Ever since the signal hypothesis was proposed in 1971, the exact nature of signal peptides
has been a focus point of research. The prediction of signal peptides and protein subcellular …

A completely reimplemented MPI bioinformatics toolkit with a new HHpred server at its core

L Zimmermann, A Stephens, SZ Nam, D Rau… - Journal of molecular …, 2018 - Elsevier
Abstract The MPI Bioinformatics Toolkit (https://toolkit. tuebingen. mpg. de) is a free, one-stop
web service for protein bioinformatic analysis. It currently offers 34 interconnected external …

Type V secretion: mechanism (s) of autotransport through the bacterial outer membrane

JC Leo, I Grin, D Linke - Philosophical Transactions of …, 2012 - royalsocietypublishing.org
Autotransport in Gram-negative bacteria denotes the ability of surface-localized proteins to
cross the outer membrane (OM) autonomously. Autotransporters perform this task with the …

The MPI bioinformatics Toolkit as an integrative platform for advanced protein sequence and structure analysis

V Alva, SZ Nam, J Söding, AN Lupas - Nucleic acids research, 2016 - academic.oup.com
Abstract The MPI Bioinformatics Toolkit (http://toolkit. tuebingen. mpg. de) is an open,
interactive web service for comprehensive and collaborative protein bioinformatic analysis. It …

Bacterial membrane transporter systems for aromatic compounds: regulation, engineering, and biotechnological applications

I Mutanda, J Sun, J Jiang, D Zhu - Biotechnology Advances, 2022 - Elsevier
Aromatic compounds are ubiquitous in nature; they are the building blocks of abundant
lignin, and constitute a substantial proportion of synthetic chemicals and organic pollutants …

PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL

E Bramucci, A Paiardini, F Bossa, S Pascarella - BMC bioinformatics, 2012 - Springer
Background In recent years, an exponential growing number of tools for protein sequence
analysis, editing and modeling tasks have been put at the disposal of the scientific …

Type V secretion systems in bacteria

E Fan, N Chauhan, DG Udatha… - … of Bacterial Pathogens, 2016 - Wiley Online Library
Gram‐negative bacteria are surrounded by two membranes, called the outer and inner
membranes. The space between these membranes, the periplasm, is spanned by a …

Discriminating outer membrane proteins with fuzzy K-nearest neighbor algorithms based on the general form of Chou's PseAAC

M Hayat, A Khan - Protein and peptide letters, 2012 - ingentaconnect.com
Outer membrane proteins (OMPs) play important roles in cell biology. In addition, OMPs are
targeted by multiple drugs. The identification of OMPs from genomic sequences and …

Efficient subfractionation of gram-negative bacteria for proteomics studies

M Thein, G Sauer, N Paramasivam, I Grin… - Journal of proteome …, 2010 - ACS Publications
Proteomics studies of pathogenic bacteria are an important basis for biomarker discovery
and for the development of antimicrobial drugs and vaccines. Especially where vaccines are …

PRED-TMBB2: improved topology prediction and detection of beta-barrel outer membrane proteins

KD Tsirigos, A Elofsson, PG Bagos - Bioinformatics, 2016 - academic.oup.com
Abstract Motivation The PRED-TMBB method is based on Hidden Markov Models and is
capable of predicting the topology of beta-barrel outer membrane proteins and discriminate …