Roles of macrophage polarization and macrophage-derived miRNAs in pulmonary fibrosis

A Kishore, M Petrek - Frontiers in immunology, 2021 - frontiersin.org
This mini-review summarizes the current evidence for the role of macrophage activation and
polarization in inflammation and immune response pertinent to interstitial lung disease …

PLGA-based micro/nanoparticles: an overview of their applications in respiratory diseases

X Guo, X Zuo, Z Zhou, Y Gu, H Zheng, X Wang… - International Journal of …, 2023 - mdpi.com
Respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD),
are critical areas of medical research, as millions of people are affected worldwide. In fact …

Application of micro RNA s in diagnosis and treatment of cardiovascular disease

A Wronska, I Kurkowska‐Jastrzebska… - Acta …, 2015 - Wiley Online Library
Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide.
Innovative, more stringent diagnostic and prognostic biomarkers and effective treatment …

Cytokine storm in the pathophysiology of COVID-19: Possible functional disturbances of miRNAs

M Aslani, SS Mortazavi-Jahromi, A Mirshafiey - International …, 2021 - Elsevier
Abstract SARS-CoV-2, as the causative agent of COVID-19, is an enveloped positives-sense
single-stranded RNA virus that belongs to the Beta-CoVs sub-family. A sophisticated hyper …

Pulmonary delivery of Nanocomposite Microparticles (NCMPs) incorporating miR-146a for treatment of COPD

A Mohamed, AY Pekoz, K Ross, GA Hutcheon… - International Journal of …, 2019 - Elsevier
The treatment and management of COPD by inhalation to the lungs has emerged as an
attractive alternative route to oral dosing due to higher concentrations of the drug being …

MicroRNAs in inflammatory heart diseases and sepsis-induced cardiac dysfunction: a potential scope for the future?

M Mirna, V Paar, R Rezar, A Topf, M Eber, UC Hoppe… - Cells, 2019 - mdpi.com
Background: MicroRNAs (miRNAs) are small, single-stranded RNA sequences that regulate
gene expression on a post-transcriptional level. In the last few decades, various trials have …

Regenerative cardiovascular therapies: stem cells and beyond

B Wernly, M Mirna, R Rezar, C Prodinger… - International journal of …, 2019 - mdpi.com
Although reperfusion therapy has improved outcomes, acute myocardial infarction (AMI) is
still associated with both significant mortality and morbidity. Once irreversible myocardial cell …

MicroRNAs: Key modulators of inflammation-associated diseases

B Chatterjee, M Sarkar, S Bose, MT Alam… - Seminars in Cell & …, 2024 - Elsevier
Inflammation is a multifaceted biological and pathophysiological response to injuries,
infections, toxins, and inflammatory mechanisms that plays a central role in the progression …

Targeting COPD with PLGA‐Based Nanoparticles: Current Status and Prospects

J Saxena, M Bisen, A Misra… - BioMed Research …, 2022 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is pulmonary emphysema characterized by
blockage in the airflow resulting in the long‐term breathing problem, hence a major cause of …

Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD)

A Mohamed, NK Kunda, K Ross, GA Hutcheon… - European Journal of …, 2019 - Elsevier
RNA interference (RNAi) based therapeutics are considered an endogenous mechanism for
modulating gene expression. In addition, microRNAs (miRNAs) may be tractable targets for …