The host cytoskeleton functions as a pleiotropic scaffold: orchestrating regulation of the viral life cycle and mediating host antiviral innate immune responses

M Li, D Peng, H Cao, X Yang, S Li, HJ Qiu, LF Li - Viruses, 2023 - mdpi.com
Viruses are obligate intracellular parasites that critically depend on their hosts to initiate
infection, complete replication cycles, and generate new progeny virions. To achieve these …

Role of Neurotropic Viruses in Brain Metastasis of Breast Cancer: Mechanisms and Therapeutic Implications

Z Qiu, X Liu, W Cao, R Li, J Yang… - Reviews in Medical …, 2024 - Wiley Online Library
Neurotropic viruses have been implicated in altering the central nervous system
microenvironment and promoting brain metastasis of breast cancer through complex …

RhoA suppresses pseudorabies virus replication in vitro

XM Li, SP Wang, JY Wang, T Tang, B Wan, L Zeng… - Virology Journal, 2023 - Springer
The porcine pseudorabies virus (PRV) is one of the most devastating pathogens and brings
great economic losses to the swine industry worldwide. Viruses are intracellular parasites …

RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation

X Liu, J Xu, M Zhang, H Wang, X Guo, M Zhao… - Journal of …, 2024 - journals.asm.org
Rabies virus (RABV) is highly lethal and triggers severe neurological symptoms. The
neuropathogenic mechanism remains poorly understood. Ras-related C3 botulinum toxin …

Host desmin interacts with RABV matrix protein and facilitates virus propagation

W Zhang, Y Liu, M Li, J Zhu, X Li, TR Luo, J Liang - Viruses, 2023 - mdpi.com
Microfilaments and microtubules, two crucial structures of cytoskeletal networks, are usurped
by various viruses for their entry, egress, and/or intracellular trafficking, including the Rabies …

[HTML][HTML] Looking at the Pathogenesis of the Rabies Lyssavirus Strain Pasteur Vaccins through a Prism of the Disorder-Based Bioinformatics

S Dhulipala, VN Uversky - Biomolecules, 2022 - mdpi.com
Rabies is a neurological disease that causes between 40,000 and 70,000 deaths every
year. Once a rabies patient has become symptomatic, there is no effective treatment for the …

Rap1b: A cytoskeletal regulator Advantageous to viral infection

B Zhang, S Li, J Ding, J Guo, Z Ma - Iscience, 2024 - cell.com
RAS-like small GTP-binding protein 1b (Rap1b) is a small GTPase involved in numerous
deformation-mediated physiological processes, including viral infection, though cytoskeleton …

Resveratrol inhibits rabies virus infection in N2a cells by activating the SIRT1/Nrf2/HO-1 pathway

Q Liu, Q He, X Tao, P Yu, S Liu, Y **e, W Zhu - Heliyon, 2024 - cell.com
Rabies is a highly lethal infectious disease with no existing treatment available, thus
investigating effective antiviral compounds to control rabies virus (RABV) infection is of …

Viruses and the Brain—A Relationship Prone to Trouble

MB Mielcarska, BT Rouse - Viruses, 2025 - mdpi.com
Neurological disorders, some of which are associated with viral infections, are growing due
to the aging and expanding population. Despite strong defenses of the central nervous …

Sex-Specific Development of ssRNA Virus Receptor Gene Expression in the Human Brain

N Halabian, L Monteiro, J Li, M Panday, KM Murphy - bioRxiv, 2023 - biorxiv.org
Background The COVID-19 pandemic has focused research on the detrimental impact of
neuroinvasive single-strand RNA (ssRNA) viruses. Those viruses cause a wide range of …