Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

Further work on mediators and pathways that are common across different models and
occur in human osteoarthritis and that impact the osteoarthritis disease process at different …

There has been an increasing demand for the development of nanocarriers targeting
multiple diseases with a broad range of properties. Due to their tiny size, giant surface area …

Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

Osteoarthritis (OA) has traditionally been classified as a noninflammatory arthritis; however,
the dichotomy between inflammatory and degenerative arthritis is becoming less clear with …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

The articular surface plays an essential role in load transfer across the joint, and conditions
that produce increased load transfer or altered patterns of load distribution accelerate the …

Healthy limb joints are important for maintaining health and attaining longevity.
Endochondral ossification (the replacement of cartilage with bone, occurring during skeletal …