Unraveling the diversity of protein-carbohydrate interfaces: insights from a multi-scale study

A Gheeraert, F Guyon, S Pérez, T Galochkina - Carbohydrate Research, 2025 - Elsevier
Protein-carbohydrate interactions play a crucial role in numerous fundamental biological
processes. Thus, description and comparison of the carbohydrate binding site (CBS) …

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric CNS tumors

RJ Corbett, RS Kaufman, SW McQuaid, Z Vaksman… - medRxiv, 2025 - medrxiv.org
The contribution of rare pathogenic/likely pathogenic (P/LP) germline variants to pediatric
central nervous system (CNS) tumor development remains understudied. Here, we …

Atlas of the Bacterial Serine-Threonine Kinases expands the functional diversity of the kinome

BM O'Boyle, W Yeung, JD Lu, S Katiyar… - bioRxiv, 2025 - biorxiv.org
Bacterial serine-threonine protein kinases (STKs) regulate diverse cellular processes
associated with cell growth, virulence, and pathogenicity. They are evolutionarily related to …

Semantic mining of functional de novo genes from a genomic language model

AT Merchant, SH King, E Nguyen, BL Hie - bioRxiv, 2024 - biorxiv.org
Generative genomics models can design increasingly complex biological systems.
However, effectively controlling these models to generate novel sequences with desired …

[PDF][PDF] Genome Sequence, Comparative Genome Analysis and Expression Profiling of Chitinase GH18 Gene Family in Cordyceps javanica Bd01

T Zhu, M Hussain, J Ning, X Chen, C Shi, D Yang… - 2025 - preprints.org
The fungus Cordyceps javanica is known for entomopathogenicity and effective in control of
various arthropods. Here, we aimed to reveal chitinase GH18 gene family expansion …

Characterizatrion of Anaerobic Growth and Biofilm Formation in Pseudomonas aeruginosa Mutant Strain Lacking Genes PA1759 and PA1760

H Burian - 2025 - ruor.uottawa.ca
Antibiotic resistance is a major problem in the 21st century. Opportunistic bacterial infections
caused by Pseudomonas aeruginosa (PA) impact individuals with compromised immune …