Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …
disorders characterized by early-onset, often severe epileptic seizures and EEG …
Pathways modulating neural KCNQ/M (Kv7) potassium channels
P Delmas, DA Brown - Nature Reviews Neuroscience, 2005 - nature.com
K+ channels play a crucial role in regulating the excitability of neurons. Many K+ channels
are, in turn, regulated by neurotransmitters. One of the first neurotransmitter-regulated …
are, in turn, regulated by neurotransmitters. One of the first neurotransmitter-regulated …
Mechanisms of action of antiseizure drugs and the ketogenic diet
Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …
treatment for people with epilepsy, but not all patients become free of seizures. The …
Modulation of Kv7 channels and excitability in the brain
DL Greene, N Hoshi - Cellular and Molecular Life Sciences, 2017 - Springer
Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …
Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated
with an inherited epilepsy syndrome. We have studied the contribution of KCNQ/M-channels …
with an inherited epilepsy syndrome. We have studied the contribution of KCNQ/M-channels …
Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after‐hyperpolarization and excitability control in CA1 hippocampal pyramidal …
In hippocampal pyramidal cells, a single action potential (AP) or a burst of APs is followed by
a medium afterhyperpolarization (mAHP, lasting∼ 0.1 s). The currents underlying the mAHP …
a medium afterhyperpolarization (mAHP, lasting∼ 0.1 s). The currents underlying the mAHP …
Potassium channels in Parkinson's disease: potential roles in its pathogenesis and innovative molecular targets for treatment
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …
Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7. 2 and Kv7. 3 potassium channel subunits
Mutations in Kv7. 2 (KCNQ2) and Kv7. 3 (KCNQ3) genes, encoding for voltage-gated K+
channel subunits underlying the neuronal M-current, have been associated with a wide …
channel subunits underlying the neuronal M-current, have been associated with a wide …
Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction
Seizures are the most common neurological manifestation in the newborn period, with an
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
estimated incidence of 1.8–3.5 per 1000 live births. Prolonged or intractable seizures have a …
Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
Members of the Kv7 family (Kv7. 2–Kv7. 5) generate a subthreshold K+ current, the M−
current. This regulates the excitability of many peripheral and central neurons. Recent …
current. This regulates the excitability of many peripheral and central neurons. Recent …