[HTML][HTML] Depression in sub-saharan Africa

IT Gbadamosi, IT Henneh, OM Aluko… - IBRO neuroscience …, 2022 - Elsevier
Mood disorders can be considered among the most common and debilitating mental
disorders. Major depression, as an example of mood disorders, is known to severely reduce …

Pathologic role of nitrergic neurotransmission in mood disorders

M Ghasemi, J Claunch, K Niu - Progress in Neurobiology, 2019 - Elsevier
Mood disorders are chronic, recurrent mental diseases that affect millions of individuals
worldwide. Although over the past 40 years the biogenic amine models have provided …

Cyclodextrins improving the physicochemical and pharmacological properties of antidepressant drugs: a patent review

TC Diniz, TCC Pinto, PP Menezes… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Depression is a serious mood disorder and is one of the most common mental
illnesses. Despite the availability of several classes of antidepressants, a substantial …

µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice

KE Nisbett, LF Vendruscolo, GF Koob - Translational Psychiatry, 2024 - nature.com
Mood and anxiety disorders are leading causes of disability worldwide and are major
contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid …

[HTML][HTML] Chrysin reverses the depressive-like behavior induced by hypothyroidism in female mice by regulating hippocampal serotonin and dopamine

VC Bortolotto, FC Pinheiro, SM Araujo… - European journal of …, 2018 - Elsevier
Hypothyroidism is often associated with psychiatric disorders such as depression. In this
study, we evaluated the effect of chrysin on depressive-like behavior and monoamine levels …

Saffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind study

G Jelodar, Z Javid, A Sahraian… - Avicenna journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Objectives: A correlation between hyperhomocysteinemia, and depression has been
reported. Saffron (Crocus sativus) is recommended for treatment of depression; hence, in …

Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism

Z **, J Ling, J Yu, M He, P Ni, F Zhang… - Experimental Brain …, 2021 - Springer
Hypothyroidism causes somatic, psychosocial and affective psychosis, including depression-
like behaviors. In this study,(hypothyroidism group; HP group) adult male Sprague Dawley …

Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress …

DW Adongo, PK Mante, KKE Kukuia, CK Benneh… - Plos one, 2023 - journals.plos.org
Introduction Pseudospondias microcarpa (Anacardiaceae) is a plant widely used
traditionally for treating various central nervous system disorders. A previous study in our …

Anxiolytic and Antidepressant Effects of Maerua angolensis DC. Stem Bark Extract in Mice

CK Benneh, RP Biney, DW Adongo… - Depression …, 2018 - Wiley Online Library
Introduction. The stem bark extract of Maerua angolensis DC.(Capparaceae) is used as a
traditional remedy for management of anxiety, psychosis, and epilepsy. Aim of the Study. We …

[HTML][HTML] Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)–new piperazine derivative with antianxiety and antidepressant-like …

DM da Silva, G Sanz, BG Vaz, FS de Carvalho… - Biomedicine & …, 2018 - Elsevier
The piperazine derivatives correspond to an extensive chemical class of compounds with
numerous neuropharmacological activities, including antidepressant (eg, nefazodone …