Prefrontal cortex and depression
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
Hot and cold executive functions in the brain: A prefrontal-cingular network
Executive functions, or cognitive control, are higher-order cognitive functions needed for
adaptive goal-directed behaviours and are significantly impaired in majority of …
adaptive goal-directed behaviours and are significantly impaired in majority of …
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
mechanisms by which ELA increases the risk for future psychopathology are still poorly …
Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?
DA Pizzagalli - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
Biological factors influencing depression in later life: role of aging processes and treatment implications
Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …
Computational psychiatry needs time and context
Why has computational psychiatry yet to influence routine clinical practice? One reason may
be that it has neglected context and temporal dynamics in the models of certain mental …
be that it has neglected context and temporal dynamics in the models of certain mental …
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): III. Emotional dysfunction superspectrum
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological
system that addresses shortcomings of traditional mental disorder diagnoses, including …
system that addresses shortcomings of traditional mental disorder diagnoses, including …
Reward-processing behavior in depressed participants relative to healthy volunteers: A systematic review and meta-analysis
Importance Dysfunctional reward processing is a leading candidate mechanism for the
development of certain depressive symptoms, such as anhedonia. However, to our …
development of certain depressive symptoms, such as anhedonia. However, to our …
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
S Wang, F Leri, SJ Rizvi - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Anhedonia is a key symptom of major depressive disorder (MDD) and comprises
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …
behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and …