In response to limitations in the understanding and use of published evidence, evidence-
based medicine (EBM) began as a movement in the early 1990s. EBM's initial focus was on …

N-of-1 or single subject clinical trials consider an individual patient as the sole unit of
observation in a study investigating the efficacy or side-effect profiles of different …

Medical practice is constantly changing. The rate of change is accelerating, and physicians
can be forgiven if they often find it dizzying. How can physicians learn about new information …

The number of innovative applications of randomization tests in various fields and recent
developments in experimental design, significance testing, computing facilities, and …

Background Adverse events related to drugs occur frequently among inpatients, and many
of these events are preventable. However, few data are available on adverse drug events …

" Thoroughly revised and updated, the second edition of Intuitive Biostatistics retains and
refines the core perspectives of the previous edition: a focus on how to interpret statistical …

Recent literature suggests a revival of interest in single-case methodology (eg, the
randomised n-of-1 trial is now considered Level 1 evidence for treatment decision purposes …

ContextMeasurement of change in patients' health status is central to both clinical trials and
clinical practice. Trials commonly use serial measurements by the patients at 2 points in time …

Rating scales that assess methodological quality of clinical trials provide a means to
critically appraise the literature. Scales are currently available to rate randomised and non …

Objective To raise awareness among clinicians and epidemiologists that single-patient (n-of-
1) trials are potentially useful for informing personalized treatment decisions for patients with …