Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers

H Jeltsch-David, S Muller - Nature Reviews Neurology, 2014 - nature.com
Systemic lupus erythematosus (SLE) is a complex clinical syndrome, elements of which
remain poorly understood. Although recognized over 140 years ago when Kaposi recorded …

Diagnosis and management of neuropsychiatric SLE

JG Hanly - Nature Reviews Rheumatology, 2014 - nature.com
Nervous system involvement in systemic lupus erythematosus (SLE) can manifest as a
range of neurological and psychiatric features, which are classified using the ACR case …

Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives

C Magro-Checa, EJ Zirkzee, TW Huizinga… - Drugs, 2016 - Springer
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a generic definition referring to a
series of neurological and psychiatric symptoms directly related to systemic lupus …

The geoepidemiology of systemic lupus erythematosus

AT Borchers, SM Naguwa, Y Shoenfeld… - Autoimmunity …, 2010 - Elsevier
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with manifold
clinical manifestations and immunological abnormalities, affecting primarily women …

The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?

M Govoni, JG Hanly - Rheumatology, 2020 - academic.oup.com
Neuropsychiatric (NP) events occur in the majority of patients with SLE and predominantly
affect the CNS in addition to the peripheral and autonomic systems. Approximately 30% of …

Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations

GK Bertsias, DT Boumpas - Nature Reviews Rheumatology, 2010 - nature.com
Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE),
but less than one-third of these events can be directly attributed to SLE. Increased …

The diagnosis and clinical management of the neuropsychiatric manifestations of lupus

M Govoni, A Bortoluzzi, M Padovan, E Silvagni… - Journal of …, 2016 - Elsevier
Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

Fatigue, health-related quality of life and other patient-reported outcomes in systemic lupus erythematosus

A Schmeding, M Schneider - Best practice & research Clinical …, 2013 - Elsevier
Objective This chapter aims to evaluate current knowledge of the burden of systemic lupus
erythematosus (SLE) on individual patients, with a particular focus on health-related quality …

Development and validation of a new algorithm for attribution of neuropsychiatric events in systemic lupus erythematosus

A Bortoluzzi, CA Scire, S Bombardieri, L Caniatti… - …, 2015 - academic.oup.com
Objective. The aim of this study was to develop and validate an algorithm to assist the
attribution of neuropsychiatric (NP) events to underlying disease in SLE patients. Methods …