Most tissues of the human body are characterized by highly anisotropic physical properties
and biological organization. Hydrogels have been proposed as scaffolding materials to …

Stem cell fate is closely intertwined with microenvironmental and endogenous cues within
the body. Recapitulating this dynamic environment ex vivo can be achieved through …

Recreating the extracellular matrix organization and cellular patterns of anisotropic tissues
in bioengineered constructs remains a significant biofabrication challenge. Magnetically …

Tissue engineering and regenerative medicine have solved numerous problems related to
the repair and regeneration of damaged organs and tissues arising from aging, illnesses …

The regenerative capabilities including self-renewal, migration and differentiation potentials
shift from the embryonic phase to the mature period of endogenous tendon stem/progenitor …

Anisotropic microarchitectures arising from an aligned organization of threadlike
extracellular matrix (ECM) components or cells are ubiquitous in the human body, such as …

Active biomaterials offer novel approaches to study mechanotransduction in mammalian
cells. These material systems probe cellular responses by dynamically modulating their …

Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair
process leaves fibrotic scar tissue with inferior mechanical properties. Surgical treatment is …

Hydrogels, as a class of three-dimensional (3D) polymer networks, are important candidates
for drug delivery owing to their high porosity and hydrophilicity. Generally, clinical …

With an increase in life expectancy and the popularity of high-intensity exercise, the
frequency of tendon and ligament injuries has also increased. Owing to the specificity of its …