BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is
within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of …

Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

A 30-year-old woman presents with a history of no menses since she stopped taking oral
contraceptives 6 months ago in order to conceive. She had undergone normal puberty, with …

Premature ovarian insufficiency is a complex and relatively poorly understood entity with a
myriad of etiologies and multisystem sequelae that stem from premature deprivation of …

Abstract Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

Premature ovarian failure (POF) is a disorder with a complicated clinical presentation and
course that is poorly defined by its name. A more scientifically accurate term for the disorder …

The FMR1 mutations can cause a variety of disabilities, including cognitive deficits, attention-
deficit/hyperactivity disorder, autism, and other socioemotional problems, in individuals with …

Premature ovarian failure (POF) is an ovarian defect characterized by the premature
depletion of ovarian follicles before the age of 40 years, representing one major cause of …

The human fragile X mental retardation 1 (FMR1) gene contains a (CGG) n trinucleotide
repeat in its 5′ untranslated region (5′ UTR). Expansions of this repeat result in a number …