Pancreatic tumors are highly desmoplastic and immunosuppressive. Delivery and
distribution of drugs within pancreatic tumors are compromised due to intrinsic physical and …

Tumor immunotherapy is an artificial stimulation of the immune system to enhance anti-
cancer response. It has become a powerful clinical strategy for treating cancer. The number …

The critical challenge for cancer vaccine‐induced T‐cell immunity is the sustained activation
of antigen cross‐presentation in antigen‐presenting cells (APCs) with innate immune …

Immunotherapy holds great promise for the treatment of aggressive and metastatic cancers;
however, currently available immunotherapeutics, such as immune checkpoint blockade …

As many diseases are related to inflammation, the inflammatory tropism of immune cells may
bring cell‐hitchhikers directly to the disease tissues in a highly targeted manner. The current …

Abstract mRNA vaccines are attractive prospects for the development of DC-targeted
vaccines; however, no clinical success has been realized because, currently, it is difficult to …

Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to its
aggressiveness and the challenges for early diagnosis and treatment. Recently …

Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …

Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there
has been an ongoing debate to what extent macrophages and DCs are related and perform …