Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - Elsevier
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

Quantum chemical modeling of the photoinduced activity of multichromophoric biosystems: focus review

F Segatta, L Cupellini, M Garavelli… - Chemical reviews, 2019 - ACS Publications
Multichromophoric biosystems represent a broad family with very diverse members, ranging
from light-harvesting pigment–protein complexes to nucleic acids. The former are designed …

Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses

T Miclot, C Hognon, E Bignon, A Terenzi… - The Journal of …, 2021 - ACS Publications
Guanine quadruplex (G4) structures in the viral genome have a key role in modulating
viruses' biological activity. While several DNA G4 structures have been experimentally …

Investigation of G-Quadruplex DNA-Mediated Charge Transport for Exploring DNA Oxidative Damage in Telomeres

Z He, J Wu, W Li, Y Du, L Lu - Langmuir, 2024 - ACS Publications
The human telomeric DNA 3′ single-stranded overhang comprises tandem repeats of the
sequence d (TTAGGG), which can fold into the stable secondary structure G-quadruplex …

Magneto-fluorescent nanobiosensor with tetrahedral framework nucleic acid-confined aptamer for trace adenosine triphosphate detection

G Huang, Q **e, J Chi, C Lin, X Lin, Z **e - Sensors and Actuators B …, 2024 - Elsevier
Accurate quantitation of trace-level ATP biomarkers often suffers from interference of sample
matrix and remains a challenge. Herein, a novel magnetic biological nanosensor (MBNS) …

Resolving a guanine-quadruplex structure in the SARS-CoV-2 genome through circular dichroism and multiscale molecular modeling

L d'Anna, T Miclot, E Bignon, U Perricone… - Chemical …, 2023 - pubs.rsc.org
The genome of SARS-CoV-2 coronavirus is made up of a single-stranded RNA fragment
that can assume a specific secondary structure, whose stability can influence the virus's …

Sensing of survivin mRNA in malignant astrocytes using graphene oxide nanocarrier-supported oligonucleotide molecular beacons

M Stobiecka, B Dworakowska, S Jakiela… - Sensors and Actuators B …, 2016 - Elsevier
While a significant progress has recently been made in therapy of many cancers, the cure for
some high grade cancers, such as the astrocytic cancers, remains elusive. In the latter case …

Excitonic model for strongly coupled multichromophoric systems: the electronic circular dichroism spectra of guanine quadruplexes as test cases

JA Green, H Asha, F Santoro… - Journal of Chemical …, 2020 - ACS Publications
We here propose a general and flexible approach, based on fragment diabatization, which
incorporates charge transfer states and significantly increases the reliability of excitonic …

Studying the excited electronic states of guanine rich DNA quadruples by quantum mechanical methods: main achievements and perspectives

L Martínez-Fernández, L Esposito, R Improta - … & Photobiological Sciences, 2020 - Springer
The main insights into the photoactivated dynamics of guanine quadruplexes (G4s) recently
provided by quantum mechanical computations are concisely reviewed here. The …

Praseodymium chloride-mediated B-to-Z DNA transition in pyrimidine-purine repeat sequences: Simulation and biophysical study

PS Nial, C Sathyaseelan, MM Bhanjadeo… - Journal of Molecular …, 2024 - Elsevier
The present study investigates the impact of praseodymium chloride on the conformational
transition between the B-form and Z-form of DNA. In the current communication, we employ …