Lymphodepletion (LD) or conditioning is an essential step in the application of currently
used autologous and allogeneic chimeric antigen receptor T-cell (CAR-T) therapies as it …

Although the majority of patients with acute myeloid leukemia (AML) treated with intensive
chemotherapy achieve a complete remission (CR), many are destined to relapse if treated …

These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Purpose Several open-label randomized studies have suggested that in vivo T-cell
depletion with anti–T-lymphocyte globulin (ATLG; formerly antithymocyte globulin …

Graft-vs. host disease (GVHD), both acute and chronic are among the chief non-relapse
complications of allogeneic transplantation which still cause substantial morbidity and …

This collaborative initiative aimed to provide recommendations on the use of polyclonal
antithymocyte globulin (ATG) or anti-T lymphocyte globulin (ATLG) for the prevention of graft …

Acute graft-versus-host disease (aGVHD) is a major life-threatening complication after
allogeneic hematopoietic cell transplant. Traditional standard prophylaxis for aGVHD has …

Background Anti-thymocyte globulin, which is used in the conditioning of haematopoietic
stem-cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft …

Slow immune reconstitution is a major obstacle to the successful use of allogeneic
hematopoietic cell transplantation (allo-HCT). As matched sibling donor (MSD) allo-HCT is …

Preventing viral infections at an early stage is a key strategy for successfully improving
transplant outcomes. Preemptive therapy and prophylaxis with antiviral agents have been …