Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

Collagens are triple helical proteins that occur in the extracellular matrix (ECM) and at the
cell–ECM interface. There are more than 30 collagens and collagen-related proteins but the …

The deleterious age-related changes in collagen that manifest in the stiffening of the joints,
the vascular system and the renal and retinal capillaries are primarily due to the …

The small-diameter fibrils of the chick corneal stroma are heterotypic, composed of both
collagen types I and V. This tissue has a high concentration of type V collagen relative to …

The vitreous gel is a transparent extracellular matrix that fills the cavity behind the lens of the
eye and is surrounded by and attached to the retina. This gel liquefies during ageing and in …

There is an interesting class of problems in the physics of polymeric materials which one
may group under the heading “semiclassical elasticity”. Herein, the question is raised how …

Articular cartilage (AC) has no or very low ability of self-repair, and untreated lesions may
lead to the development of osteoarthritis. One method that has been proven to result in long …

This review will focus on the molecular organisation of the adult vitreous and how it
undergoes ageing changes throughout life that result in vitreous liquefaction and a …

Hyaline cartilage contains five well‐characterized proteoglycans in its extracellular matrix,
and it is likely that others exist. The largest in size and most abundant by weight is aggrecan …

The distribution of collagen XI in fibril fragments from 17-d chick embryo sternal cartilage
was determined by immunoelectron microscopy using specific polyclonal antibodies. The …