The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of
tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in …

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the
nuclei of endothelial and epithelial cells of barrier tissues, among others. It functions as an …

Inflammation is a prominent feature of ischemia-reperfusion injury (IRI), which is
characterized by leukocyte infiltration and renal tubular injury. However, signals that initiate …

Type 2 diabetes mellitus (T2DM) is a disease with a drastically growing worldwide
prevalence. It is usually associated with numerous complications of which; diabetic …

Acute kidney injury caused by ischemia-reperfusion injury (IRI) is a major risk factor for
chronic kidney disease, which is characterized by renal interstitial fibrosis. However, the …

Introduction Inflammation is a significant contributor to cardiorenal morbidity and mortality in
diabetic kidney disease (DKD). The pathophysiological mechanisms linking systemic …