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The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections
R Yang, E Hou, W Cheng, X Yan, T Zhang… - Journal of Medicinal …, 2022 - ACS Publications
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to
endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its …
endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its …
Advances of peptides for antibacterial applications
Y Yan, Y Li, Z Zhang, X Wang, Y Niu, S Zhang… - Colloids and Surfaces B …, 2021 - Elsevier
In the past few decades, peptide antibacterial products with unique antibacterial
mechanisms have attracted widespread interest. They can effectively reduce the probability …
mechanisms have attracted widespread interest. They can effectively reduce the probability …
Biocatalytic nanomaterials: A new pathway for bacterial disinfection
Clinical treatment of pathogenic infection has emerged as a growing challenge in global
public health. Such treatment is currently limited to antibiotics, but abuse of antibiotics have …
public health. Such treatment is currently limited to antibiotics, but abuse of antibiotics have …
Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections
There has been a dramatic increase in the emergence of antibiotic‐resistant bacterial
strains, which has made antibiotic choices for infection control increasingly limited and more …
strains, which has made antibiotic choices for infection control increasingly limited and more …
Bioconjugation with maleimides: a useful tool for chemical biology
Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …
Enzyme mimics for engineered biomimetic cascade nanoreactors: mechanism, applications, and prospects
Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding
highly efficient and selective transformations of substrates. Inspired by the merits of these …
highly efficient and selective transformations of substrates. Inspired by the merits of these …
Targeting antibiotic resistance
Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …
challenge for the life sciences community and for public health. The past decades have seen …
Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria
We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-
resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface …
resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface …