The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

R Yang, E Hou, W Cheng, X Yan, T Zhang… - Journal of Medicinal …, 2022 - ACS Publications
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) continue to
endanger public health. Here, we report the synthesis of neolignan isomagnolone (I) and its …

Advances of peptides for antibacterial applications

Y Yan, Y Li, Z Zhang, X Wang, Y Niu, S Zhang… - Colloids and Surfaces B …, 2021 - Elsevier
In the past few decades, peptide antibacterial products with unique antibacterial
mechanisms have attracted widespread interest. They can effectively reduce the probability …

Biocatalytic nanomaterials: A new pathway for bacterial disinfection

X Fan, F Yang, C Nie, L Ma, C Cheng… - Advanced …, 2021 - Wiley Online Library
Clinical treatment of pathogenic infection has emerged as a growing challenge in global
public health. Such treatment is currently limited to antibiotics, but abuse of antibiotics have …

Bacteria antibiotic resistance: New challenges and opportunities for implant‐associated orthopedic infections

B Li, TJ Webster - Journal of Orthopaedic Research®, 2018 - Wiley Online Library
There has been a dramatic increase in the emergence of antibiotic‐resistant bacterial
strains, which has made antibiotic choices for infection control increasingly limited and more …

Bioconjugation with maleimides: a useful tool for chemical biology

JMJM Ravasco, H Faustino, A Trindade… - … –A European Journal, 2019 - Wiley Online Library
Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …

Enzyme mimics for engineered biomimetic cascade nanoreactors: mechanism, applications, and prospects

X Zhang, G Li, G Chen, D Wu, Y Wu… - Advanced Functional …, 2021 - Wiley Online Library
Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding
highly efficient and selective transformations of substrates. Inspired by the merits of these …

Targeting antibiotic resistance

MF Chellat, L Raguž, R Riedl - … Chemie International Edition, 2016 - Wiley Online Library
Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria

X Li, SM Robinson, A Gupta, K Saha, Z Jiang… - ACS …, 2014 - ACS Publications
We present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-
resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface …