A quantitative review of heterozygosity–fitness correlations in animal populations

JR Chapman, S Nakagawa, DW Coltman… - Molecular …, 2009 - Wiley Online Library
The ease of obtaining genotypic data from wild populations has renewed interest in the
relationship between individual genetic diversity and fitness‐related traits (heterozygosity …

Assessment of identity disequilibrium and its relation to empirical heterozygosity fitness correlations: a meta‐analysis

JM Miller, DW Coltman - Molecular Ecology, 2014 - Wiley Online Library
Heterozygosity fitness correlations (HFC s) have frequently been used to detect inbreeding
depression, under the assumption that genome‐wide heterozygosity is a good proxy for …

Multi-generational benefits of genetic rescue

DP Onorato, MW Cunningham, M Lotz, M Criffield… - Scientific Reports, 2024 - nature.com
Genetic rescue—an increase in population fitness following the introduction of new alleles—
has been proven to ameliorate inbreeding depression in small, isolated populations, yet is …

Conservation genetics of population bottlenecks: the role of chance, selection, and history

JL Bouzat - Conservation Genetics, 2010 - Springer
Conservation genetics studies of populations bottlenecks are commonly framed under the
detrimental paradigm of inbreeding depression. This conceptual paradigm presupposes a …

From reference genomes to population genomics: comparing three reference-aligned reduced-representation sequencing pipelines in two wildlife species

B Wright, KA Farquharson, EA McLennan, K Belov… - BMC genomics, 2019 - Springer
Background Recent advances in genomics have greatly increased research opportunities
for non-model species. For wildlife, a growing availability of reference genomes means that …

Estimating genome-wide heterozygosity: effects of demographic history and marker type

JM Miller, RM Malenfant, P David, CS Davis, J Poissant… - Heredity, 2014 - nature.com
Heterozygosity–fitness correlations (HFCs) are often used to link individual genetic variation
to differences in fitness. However, most studies examining HFCs find weak or no …

Specific alleles at immune genes, rather than genome‐wide heterozygosity, are related to immunity and survival in the critically endangered Attwater's prairie‐chicken

ZW Bateson, SC Hammerly, JA Johnson… - Molecular …, 2016 - Wiley Online Library
The negative effects of inbreeding on fitness are serious concerns for populations of
endangered species. Reduced fitness has been associated with lower genome‐wide …

Reduced heterozygosity impairs sperm quality in endangered mammals

JL Fitzpatrick, JP Evans - Biology letters, 2009 - royalsocietypublishing.org
Inbreeding causes increases in homozygosity and is commonly associated with reductions
in fertility and embryogenesis. Although the mechanisms underlying such effects are …

A dominance hypothesis argument for historical genetic gains and the fixation of heterosis in octoploid strawberry

MJ Feldmann, DDA Pincot, DK Seymour, RA Famula… - Genetics, 2024 - academic.oup.com
Heterosis was the catalyst for the domestication of cultivated strawberry (F ragaria×
ananassa), an interspecific hybrid species that originated in the 1700s. The hybrid origin …

Conservation planning for adaptive and neutral evolutionary processes

JO Hanson, A Marques, A Verissimo… - Journal of Applied …, 2020 - Wiley Online Library
Protected area systems should ideally maintain adaptive and neutral evolutionary
processes. To achieve this, plans for expanding protected area systems (prioritizations) can …