Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Cytochrome P450 monooxygenases (P450s) are versatile biocatalysts that catalyze the
regio-and stereospecic oxidation of non-activated hydrocarbons under mild conditions …

Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate
comparison with the mechanistic categorizations of cascade reactions by synthetic chemists …

Nonribosomal peptide synthetases (NRPSs) are incredible macromolecular machines that
produce a wide range of biologically-and therapeutically-relevant molecules. During …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

The development of catalytic systems for the controlled oxidation of C–H bonds remains a
highly sought-after goal in chemistry owing to the great utility of such transformation toward …

Cyclization of linear peptides is an effective strategy to convert flexible molecules into rigid
compounds, which is of great significance for enhancing the peptide stability and bioactivity …

Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Cytochrome P450 (P450) enzymes are some of the most versatile redox proteins known.
The basic P450 reactions include C-hydroxylation, heteroatom oxygenation, heteroatom …