International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …
and various drugs in development. Their diversity of structure and function reflects the …
Therapeutic potential of pyrrole and pyrrolidine analogs: an update
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …
been a versatile field of study for a long time for its diverse biological and medicinal …
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a …
Structural mechanism of muscle nicotinic receptor desensitization and block by curare
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes
the membrane and thereby triggers muscle contraction. We sought to understand at the level …
the membrane and thereby triggers muscle contraction. We sought to understand at the level …
The nicotinic acetylcholine receptor and its pentameric homologs: toward an allosteric mechanism of signal transduction at the atomic level
M Cecchini, PJ Corringer… - Annual Review of …, 2024 - annualreviews.org
The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …
Agonist selectivity and ion permeation in the α3β4 ganglionic nicotinic receptor
Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
neurotransmission. The α3β4 nicotinic receptor subtype forms the principal relay between …
Direct structural insights into GABAA receptor pharmacology
GABA A receptors are pentameric ligand-gated ion channels that mediate most fast
neuronal inhibition in the brain. In addition to their important physiological roles, they are …
neuronal inhibition in the brain. In addition to their important physiological roles, they are …
Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor
Fast synaptic communication requires receptors that respond to the presence of
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …
neurotransmitter by opening an ion channel across the post-synaptic membrane. The …
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Nanobodies are popular and versatile tools for structural biology. They have a compact
single immunoglobulin domain organization, bind target proteins with high affinities while …
single immunoglobulin domain organization, bind target proteins with high affinities while …
Mechanism of gating and partial agonist action in the glycine receptor
Ligand-gated ion channels mediate signal transduction at chemical synapses and transition
between resting, open, and desensitized states in response to neurotransmitter binding …
between resting, open, and desensitized states in response to neurotransmitter binding …